In this horror thriller, a group of five young college students in a rural cabin are confronted with an old man who needs their help. Instead of providing this poor person with assistance, they shoot him, beat him and light him on fire. The next morning, they discover that their vehicle has broken down. Bert (James DeBellow) and Jeff (Joey Kern) leave in search of a mechanic. Marcy (Cerina Vincent) feels remorseful for what the group did to the old man, so she leaves alone to find the authorities. Left by themselves, Paul (Rider Strong) and Karen (Jordan Ladd) develop their romantic relationship. Karen contracts a horrible illness and becomes grotesquely disfigured. In their fear of contracting the disease from each other, the friends turn on one another. The local residents band together in an attempt to eradicate the disease.